Human Antibody Production in Transgenic Animals
نویسندگان
چکیده
منابع مشابه
Protein Production in Transgenic Animals
developments in biotechnology provide different methods for making products. How the industry responds to the new challenges will, to a large extent, be governed by the attitudes of the consumer. One of the major effects of biotechnology will be the altering of consumers’ attitudes towards farm crops. Future farms will produce food more efficiently, perhaps in environments where originally it w...
متن کاملAntibody production in transgenic plants.
Introduction In recent years, methods have been developed for the expression of immunoglobulin-encoding genes in a wide range of heterologous organisms, including non-lymphoid mammalian cells, insect cells, yeast, bacteria and plants. The isolation of antibodyencoding genes from hybridoma cells and their expression in these heterologous hosts has led to a revolution in monoclonal antibody techn...
متن کاملProduction of human polyclonal antibodies by transgenic animals
Polyclonal antibodies collected from the blood of animals and humans experimentally immunised or spontaneously immunised respectively can be injected into patients to protect them against pathogens, toxins, tumours etc. This approach is severely limited by the availability of human polyclonal antibodies of interest. Moreover, polyclonal antibodies from animals are recognised as antigens by pati...
متن کاملProduction of pharmaceutical proteins by transgenic animals.
Proteins started being used as pharmaceuticals in the 1920s with insulin extracted from pig pancreas. In the early 1980s, human insulin was prepared in recombinant bacteria and it is now used by all patients suffering from diabetes. Several other proteins and particularly human growth hormone are also prepared from bacteria. This success was limited by the fact that bacteria cannot synthesize c...
متن کاملHuman antibody expression in transgenic mice.
Human antibody repertoires can be created in transgenic mice following the introduction of human immunoglobulin heavy and light chain genes in their germline configuration. Transgene constructs or transloci have been obtained by plasmid assembly, cloning in yeast artificial chromosomes, and the use of chromosome fragments. Translocus integration and maintenance in transgenic mouse strains has b...
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ژورنال
عنوان ژورنال: Archivum Immunologiae et Therapiae Experimentalis
سال: 2014
ISSN: 0004-069X,1661-4917
DOI: 10.1007/s00005-014-0322-x